View source for COQ-10 Deficiency

== What Does It Mean? ==
Coenzyme Q10 (CoQ10) is a vital antioxidant and a key component in mitochondrial energy production. It plays a crucial role in ATP synthesis, cellular protection, and cardiovascular health. A deficiency in CoQ10 can lead to impaired energy production, increased oxidative stress, and reduced cellular function, affecting multiple organ systems.

== How Did We Get There? ==

=== Root Causes: ===

* Aging: CoQ10 levels naturally decline with age.
* Chronic Disease States: Conditions like cardiovascular disease, neurodegenerative disorders, and diabetes deplete CoQ10 levels.
* Statin Use: Statin medications inhibit HMG-CoA reductase, the enzyme needed for CoQ10 synthesis.
* Mitochondrial Dysfunction: Impaired energy production leads to increased demand for CoQ10.
* Poor Nutrient Absorption: GI issues, dysbiosis, or liver dysfunction can impair CoQ10 absorption.

=== Signs & Symptoms: ===

* Chronic fatigue and low energy levels
* Muscle weakness, cramping, or pain (especially in statin users)
* Brain fog, cognitive decline, and memory issues
* Cardiovascular concerns (high blood pressure, heart palpitations)
* Increased susceptibility to oxidative stress and inflammation
* Poor exercise tolerance and prolonged recovery times

=== Lab Test Findings ===
{| class="wikitable"
|'''Lab Test Name'''
|'''Expected Changes'''
|'''Optimal Range'''
|-
|Coenzyme Q10
|Decreased
|1.0-2.0 ug/mL
|}

== How Do We Treat It? ==

=== Functional Medicine Approach ===
The treatment protocol aims to replenish CoQ10 levels, improve mitochondrial function, and enhance overall cellular energy production.

=== Supplement Protocol ===
{| class="wikitable"
|'''Supplement''' 
|'''Function'''
|'''Dosage & Frequency'''
|-
|CoQ-10 300 mg
|Supports mitochondrial ATP production and antioxidant function
|2 capsules with food, daily
|}

=== Additional Lifestyle Interventions: ===

* Optimize Diet: Increase intake of CoQ10-rich foods (fatty fish, organ meats, nuts, and seeds).
* Manage Statin-Induced Deficiency: If applicable, consider CoQ10 supplementation alongside statin therapy.
* Improve Mitochondrial Health: Engage in regular physical activity and intermittent fasting.
* Reduce Oxidative Stress: Consume antioxidant-rich foods and minimize environmental toxin exposure.
* Support Cellular Energy Production: Ensure adequate sleep and hydration.