Kelly.oconnor: Created

2025-05-08T20:16:54Z

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== What Does It Mean? ==
Celiac disease is a chronic autoimmune disorder triggered by the ingestion of gluten, a protein found in wheat, barley, and rye. In individuals with celiac disease, gluten consumption leads to an immune-mediated attack on the small intestinal lining, resulting in inflammation, villous atrophy, and malabsorption of essential nutrients.

== How Did We Get There? ==

=== Root Causes: ===

* Genetic Predisposition – Strong association with HLA-DQ2 and HLA-DQ8 genetic markers.
* Immune Dysregulation – Gluten exposure triggers an autoimmune response leading to chronic inflammation.
* Increased Intestinal Permeability ("Leaky Gut") – Damage to the intestinal barrier allows for immune system activation and systemic inflammation.
* Microbiome Imbalance – Dysbiosis exacerbates immune dysfunction and inflammation.
* Nutrient Deficiencies – Chronic malabsorption leads to deficiencies in iron, B vitamins, fat-soluble vitamins, and magnesium.
* Chronic Inflammation – Persistent immune activation contributes to oxidative stress and systemic effects.

=== Signs & Symptoms: ===

* Chronic diarrhea, constipation, bloating, and abdominal pain
* Fatigue and brain fog
* Unexplained weight loss or failure to thrive
* Iron-deficiency anemia
* Joint pain and muscle weakness
* Skin rashes (dermatitis herpetiformis)
* Depression, anxiety, and mood disorders
* Osteopenia or osteoporosis due to malabsorption of calcium and vitamin D

=== Lab Test Findings ===
Below are the expected lab abnormalities in Celiac Disease and their optimal reference ranges.
{| class="wikitable"
|'''Lab Test Name'''
|'''Expected Changes'''
|'''Optimal Range'''
|-
|Blood (Cell Count)
|Altered
|Negative
|-
|Celikey tTG IgA
|Increased
|0-0.2 U/mL
|-
|Celikey tTG IgG
|Increased
|0 U/mL
|-
|Ferritin (Iron Storage)
|Decreased
|45.00-79.00 ng/mL
|-
|Gliadin, Deamidated Peptide IgA (Gluten)
|Increased
|0-0.2 U/mL
|-
|Gliadin, Deamidated Peptide IgG (Gluten)
|Increased
|0-0.2 U/mL
|-
|Hemoglobin
|Decreased
|13.50-14.50 g/dL
|-
|IgE, Serum
|Normal or Increased
|90.00-220.00 IU/mL
|-
|RBC’s
|Present
|None
|}

== How Do We Treat It? ==
A functional medicine approach focuses on eliminating gluten exposure, repairing the gut lining, reducing inflammation, and replenishing lost nutrients.

=== Supplement Protocol ===
{| class="wikitable"
|'''Supplement'''
|''' Function'''
|'''Dosage & Frequency'''
|-
|Advanced Vita-Biotic R
|Supports gut microbiome & immune function
|1 capsule with food daily
|-
|Endura
|Electrolyte balance & hydration support
|1 packet with or without food, three times daily
|-
|D-Mannose Powder
|Prevents bacterial adhesion to gut lining
|1 tsp of powder with food, twice daily
|-
|Vita-Digestyzyme
|Supports digestion & enzymatic function
|2 capsule 20-30 minutes prior to food, twice daily
|-
|Vita-Candid
|Antifungal & microbiome support
|2 capsule 20-30 minutes prior to food, twice daily
|-
|CoQ-10 300 mg
|Mitochondrial & cardiovascular support
|2 capsules with food, daily
|-
|V-Inflamma
|Reduces systemic inflammation
|1 capsule without food, daily
|-
|Vita DIM
|Hormonal & detoxification support
|2 capsules with or without food, daily
|-
|Vita Defense
|Immune system support
|1 capsule without food, daily
|-
|Vita-Glutathione
|Antioxidant & cellular detoxification
|1 capsule with or without food, daily
|-
|V-Pax
|Neurotransmitter & adrenal support
|2 capsules with food, twice daily
|-
|Vita B Methyl
|Supports methylation & energy production
|1 capsule without food, daily
|-
|Magnesium
|Supports muscle function & relaxation
|2 capsule with or without food, daily
|-
|V-Collagen
|Supports gut lining & joint health
|1 scoop of powder without food, daily
|-
|SBI Powder
|Immunoglobulin support for gut healing
|1 scoop of powder in cold liquids, daily
|-
|Gluta Protect
|Antioxidant & gut barrier protection
|1 scoop of powder without food, daily
|-
|Vita Microbe
|Comprehensive probiotic support
|3 capsules with or without food, daily
|-
|Vita Buffered C Powder
|Immune & antioxidant support
|¼ scoop of powder with food, daily
|-
|Vita-Biotic
|Supports microbiome balance
|4 capsule without food, daily
|-
|Vita-Flux
|Nitric oxide & vascular health support
|2 capsules 20-30 minutes prior to food, twice daily
|}

=== Additional Lifestyle Interventions: ===

* Strict Gluten-Free Diet: Eliminate all gluten-containing foods, including wheat, barley, and rye.
* Gut Healing Foods: Increase intake of bone broth, collagen, fermented foods, and fiber-rich vegetables.
* Nutrient Repletion: Supplement with iron, B vitamins, vitamin D, and magnesium to address deficiencies.
* Reduce Inflammatory Triggers: Avoid processed foods, refined sugars, and excessive dairy.
* Manage Stress: Incorporate relaxation techniques such as meditation, yoga, and deep breathing exercises.
* Monitor for Secondary Conditions: Regularly assess for osteoporosis, thyroid dysfunction, and adrenal fatigue.

Celiac Disease - Revision history

Kelly.oconnor: Created