Kelly.oconnor: Created

2025-05-08T01:11:53Z

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== What Does It Mean? ==
Liver dysfunction refers to any condition that impairs the liver’s ability to perform its critical functions, including detoxification, metabolism, and protein synthesis. Common causes include:

* Chronic alcohol use
* Viral infections (Hepatitis B, C)
* Exposure to environmental toxins and heavy metals
* Fatty liver disease (NAFLD/NASH)
* Chronic medication use (NSAIDs, acetaminophen, certain antibiotics)

== How Did We Get There? ==

=== Diagnosis & Assessment ===
Patients with liver dysfunction may present with:

* Fatigue and weakness
* Jaundice (yellowing of the skin and eyes)
* Abdominal pain (especially in the upper right quadrant)
* Dark urine and pale stool
* Nausea and loss of appetite
* Swelling in the legs or abdomen due to fluid retention

=== Lab Test Findings ===
The following lab markers help diagnose liver dysfunction and assess its severity:
{| class="wikitable"
|'''Lab Test'''
|'''Expected Change'''
|'''Optimal Range'''
|-
|Albumin
|Decreased
|4.50-5.00 g/dL
|-
|Albumin : Globulin Ratio
|Altered
|1.40-2.10
|-
|Alkaline Phosphatase
|Increased
|45.00-100.00 U/L
|-
|ALT (SGPT)
|Increased
|10.00-26.00 U/L
|-
|AST (SGOT)
|Increased
|10.00-26.00 U/L
|-
|AST (SGOT) : ALT (SGPT) Ratio
|Altered
|0.00-1.00
|-
|Bilirubin (urine)
|Increased
|Negative mg/dL
|-
|Bilirubin Direct
|Increased
|0.10-0.15 mg/dL
|-
|Bilirubin, Total
|Increased
|0.50-0.90 mg/dL
|-
|Blood Urea Nitrogen (BUN)
|Altered
|10.00-16.00 mg/dL
|-
|Ceruloplasmin
|Altered
|18.00-21.00 mg/dL
|-
|Cholesterol, Serum
|Normal or Increased
|180.00-200.00 mg/dL
|-
|Color
|May indicate bile pigment presence
|YELLOW
|-
|Ferritin
|Altered
|45.00-79.00 ng/mL
|-
|Glutathione
|Decreased
|373.00-838.00 µM
|-
|Iron, Total
|Altered
|85.00-130.00 µg/dL
|-
|Lactate Dehydrogenase (LDH)
|Increased
|140.00-200.00 U/L
|-
|Monocyte Abs
|Altered
|0.22-0.60 Cells/µL
|-
|Total Protein
|Altered
|6.90-7.4 g/dL
|-
|Triglycerides, Serum
|Normal or Increased
|70.00-80.00 mg/dL
|-
|Uric Acid (Male)
|Increased
|3.50-5.40 mg/dL
|-
|Urobilinogen
|Altered
|Negative
|-
|Vitamin D 25-Hydroxy
|Decreased
|50.00-90.00 ng/mL
|}

== How Do We Treat It? ==

=== Functional Medicine Approach ===
Treatment focuses on reducing liver inflammation, enhancing detoxification, and supporting hepatocyte regeneration through targeted supplementation.

=== Supplement Protocol ===
{| class="wikitable"
|'''Supplement'''
|'''Function'''
|'''Dosage & Frequency'''
|-
|V-Inflamma
|Reduces systemic inflammation
|4 capsules without food, daily
|-
|Levo Plasmin
|Supports circulation and hepatic detoxification
|1 capsule without food, twice daily
|-
|Vita-Glutathione
|Master antioxidant that aids in liver detoxification
|3 capsules with or without food, daily
|-
|CoQ-10 300 mg
|Provides antioxidant support and cellular energy
|1 capsule with food, daily
|-
|Novo Hepatic
|Supports liver function and bile production
|1 capsule without food, daily
|-
|Vita DIM
|Supports hormonal balance and liver detox pathways
|2 capsules with or without food, daily
|-
|Vita-Omega
|Provides essential fatty acids for liver and metabolic health
|2 capsules with food, daily
|-
|Vita-Biotic
|Supports gut microbiome, essential for liver detox
|1 capsule without food, daily
|}

=== Additional Lifestyle Interventions: ===

* Hydration: Increase purified water intake to support detoxification
* Dietary Adjustments: Emphasize whole foods, avoid processed fats, and include liver-supporting foods like beets, cruciferous vegetables, and turmeric
* Avoid Alcohol and Toxins: Reduce liver burden by eliminating alcohol and minimizing exposure to chemicals
* Gut Health Support: Improve microbiome balance to support liver detox pathways

Liver Dysfunction - Revision history

Kelly.oconnor: Created