Kelly.oconnor: Created

2025-05-07T18:56:57Z

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== What Does It Mean? ==
Thiamine (Vitamin B1) is an essential water-soluble vitamin required for carbohydrate metabolism, ATP production, and nervous system function. A deficiency in thiamine can lead to neurological impairments, metabolic dysfunction, and cardiovascular issues.

== How Did We Get There? ==

=== Root Causes: ===

* Poor Dietary Intake – Low consumption of whole grains, legumes, and lean proteins.
* Malabsorption Disorders – Conditions like celiac disease, Crohn’s disease, and chronic alcoholism impair nutrient absorption.
* Excessive Alcohol Use – Increases thiamine excretion and decreases absorption.
* High Carbohydrate Diets – Increased carbohydrate metabolism raises thiamine requirements.
* Chronic Illness & Metabolic Dysfunction – Increased demand for thiamine in high metabolic states.

=== Signs & Symptoms: ===

* Fatigue and muscle weakness
* Peripheral neuropathy (tingling, numbness, burning sensations)
* Cognitive impairment and memory loss
* Cardiovascular symptoms (tachycardia, edema, low blood pressure)
* Poor coordination and balance (ataxia)
* Mood disturbances such as irritability or depression

== Lab Test Findings ==
{| class="wikitable"
|'''Lab Test Name'''
|'''Expected Change'''
|'''Optimal Range'''
|-
|Anion Gap
|Increased
|7.00-12.00 mEq/L
|-
|Carbon Dioxide
|Decreased
|25.00-30.00 mEq/L
|-
|Glucose, Serum
|Increased
|75.00-86.00 mg/dL
|-
|Lactate Dehydrogenase (LDH)
|Increased
|140.00-200.00 U/L
|-
|Hemoglobin (Female)
|Decreased
|13.50-14.50 g/dL
|-
|Vitamin B1 (Thiamine)
|Decreased
|78.00-185.00 ng/mL
|-
|Apoliopoprotein B (Male)
|Normal or Decreased
|52.00-117.00 mg/dL
|}

== How Do We Treat It? ==

=== Functional Medicine Approach: ===
Correcting thiamine deficiency involves dietary improvements, gut health support, and targeted supplementation.

=== Supplement Protocol ===
{| class="wikitable"
|'''Supplement'''
|'''Function'''
|'''Dosage & Frequency'''
|-
|Methyl B Complete
|Provides essential cofactors for ATP production and neurological support
|1 capsule without food, daily
|}

=== Additional Lifestyle Interventions: ===

* Increase Thiamine-Rich Foods: Whole grains, nuts, seeds, legumes, and lean meats.
* Reduce Alcohol Intake: Minimize alcohol consumption to enhance nutrient absorption.
* Support Gut Health: Optimize digestion with probiotics and enzymes to improve nutrient uptake.
* Monitor High Carbohydrate Intake: Balance macronutrient intake to prevent increased thiamine demand.

Thiamine Deficiency - Revision history

Kelly.oconnor: Created