Kelly.oconnor: Created

2025-05-07T21:42:15Z

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== What Does It Mean? ==
Wilson's Disease is a rare inherited disorder that results in excessive copper accumulation in the liver, brain, and other organs due to a mutation in the ATP7B gene. This leads to copper toxicity, causing hepatic and neurological damage if left untreated.

== How Did We Get There? ==

=== Root Causes: ===

* Genetic Mutation – Mutations in the ATP7B gene impair copper transport and excretion.
* Copper Accumulation – The body is unable to properly eliminate excess copper, leading to toxic buildup.
* Liver Dysfunction – The liver’s inability to excrete copper results in hepatocellular damage.
* Neurological Impairment – Copper accumulation in the brain affects motor function and cognition.

=== Signs & Symptoms: ===

* Liver Symptoms: Fatigue, jaundice, hepatomegaly, cirrhosis.
* Neurological Symptoms: Tremors, dystonia, difficulty speaking, cognitive decline.
* Psychiatric Symptoms: Depression, anxiety, mood swings.
* Kayser-Fleischer Rings: Copper deposits in the cornea, visible as a brownish ring around the iris.

== Lab Test Findings ==
{| class="wikitable"
|'''Lab Test Name'''
|'''Expected Change'''
|'''Optimal Range'''
|-
|ALT (SGPT)
|Increased
|10.00-26.00 IU/L
|-
|AST (SGOT)
|Increased
|10.00-26.00 IU/L
|-
|AST:ALT Ratio
|Elevated
|0.00-1.00 Ratio
|-
|Ceruloplasmin
|Decreased
|18.00-21.00 mg/dL
|-
|Copper, Serum

Homocysteine
|Increased

Increased
|90.00-150.00 ug/dL

5.00-7.20 µmol/L
|}

== How Do We Treat It? ==

=== Functional Medicine Approach: ===
Management involves reducing copper absorption, promoting detoxification, and supporting liver health.

=== Supplement Protocol ===
{| class="wikitable"
|'''Supplement'''
|''' Function'''
|'''Dosage & Frequency'''
|-
|Vita-Biotic
|Supports microbiome balance
|4 capsule without food, daily
|-
|Magnesium
|Supports muscle function & relaxation
|2 capsules with or without food, daily
|-
|V-Inflamma
|Reduces systemic inflammation
|1 capsule without food, daily
|-
|Zinc
|Supports immune function and overall health
|1 capsule with food, daily
|-
|Vita Buff-C Caps
|Antioxidant support, boost immunity, and promote collagen synthesis
|2 capsules with food, daily
|-
|V-Pax
|Neurotransmitter & adrenal support
|2 capsules with food, twice daily
|-
|Vita DIM
|Hormonal & detoxification support
|2 capsules with or without food, daily
|-
|Vita-Glutathione
|Antioxidant & cellular detoxification
|1 capsule with or without food, daily
|-
|Advaclear
|Supports detoxification, liver function, and metabolic balance with key nutrients and antioxidants
|2 capsules with or without food, daily
|-
|Vita B Methyl
|Supports methylation & energy production
|1 capsule without food, daily
|}

=== Additional Lifestyle Interventions: ===

* Low-Copper Diet: Avoid copper-rich foods (shellfish, nuts, chocolate, liver).
* Liver Support: Incorporate liver-friendly nutrients such as milk thistle and N-acetylcysteine (NAC).
* Stress Management: Reduce stress to minimize neurological symptoms.
* Medical Monitoring: Regular liver function tests and copper assessments.

Wilson's Disease - Revision history

Kelly.oconnor: Created