Anemia B6
What Does It Mean?
Anemia due to vitamin B6 deficiency occurs when the body lacks sufficient pyridoxine (B6), leading to impaired hemoglobin production and red blood cell (RBC) function. This results in microcytic anemia and neurological disturbances due to its critical role in neurotransmitter synthesis.
Key Physiological Imbalances:
- Impaired Hemoglobin Synthesis: Leads to microcytic, hypochromic anemia.
- Elevated Homocysteine Levels: Increased cardiovascular and neurological risks.
- Neurotransmitter Deficiency: Affects serotonin, dopamine, and GABA levels, leading to mood disturbances.
- Liver Enzyme Imbalances: Alters AST/ALT ratios due to its role in amino acid metabolism.
How Did We Get There?
Root Causes:
- Insufficient dietary intake (low B6-rich foods such as poultry, fish, and bananas)
- Chronic alcohol consumption interfering with B6 metabolism
- Certain medications depleting B6 levels (e.g., isoniazid, hydralazine, oral contraceptives)
- Chronic kidney disease affecting vitamin B6 status
- Liver dysfunction impacting B6-dependent enzymatic processes
Signs & Symptoms:
- Fatigue and weakness
- Irritability, depression, and mood instability
- Peripheral neuropathy (tingling, numbness)
- Glossitis (inflamed tongue) and mouth sores
- Cognitive difficulties, including brain fog
- Increased homocysteine levels contributing to cardiovascular risk
Diagnostic Criteria:
Diagnosis is based on clinical presentation and laboratory testing.
Lab Test Findings
| Lab Test | Expected Changes | Optimal Ranges |
| AST (SGOT) : ALT (SGPT) Ratio | Increased | 0.00-1.00 |
| Hemoglobin | Decreased | 13.50-14.50 g/dL |
| Homocysteine | Increased | 5.00-7.20 µmol/L |
| Iron, Total | Decreased | 85.00-130.00 µg/dL |
| MCH | Decreased | 28.00-31.90 pg |
| MCHC | Decreased or Normal | 32.00-35.00 g/dL |
| MCV | Decreased | 82.00-89.00 fL |
| Vitamin B6 (Pyridoxal-5-Phosphate), Serum | Decreased | 8.00-21.70 ng/ml |
How Do We Treat It?
Treatment focuses on replenishing vitamin B6 levels, improving absorption, and addressing underlying causes.
Supplement Protocol
| Supplement | Function | Dosage & Frequency |
| Vita B Methyl | Provides bioavailable B6 and supports methylation pathways | 1 capsule without food, daily |
Additional Lifestyle Interventions:
- Increase B6-Rich Foods: Include poultry, fish, bananas, and fortified cereals.
- Support Liver Function: Reduce alcohol intake and address liver enzyme imbalances.
- Monitor Medication Interactions: Consider B6 supplementation if on medications that deplete B6.
- Manage Stress: Support adrenal function and neurotransmitter balance with stress management techniques.