Hormone Toxicity
What Does It Mean?
Hormone toxicity occurs when excess hormones accumulate in the body, leading to inflammation, endocrine disruption, metabolic dysfunction, and systemic imbalances. This may be caused by poor hormone metabolism, impaired detoxification, excessive exogenous hormone exposure, or environmental endocrine disruptors.
Root Causes & Imbalances
- Elevated estrogen, testosterone, or dihydrotestosterone (DHT) leading to metabolic and reproductive dysfunction
- Reduced liver detoxification and hormone clearance, leading to hormone buildup
- Exposure to endocrine disruptors (plastics, pesticides, synthetic hormones) affecting hormone metabolism
- Chronic stress and adrenal dysfunction, disrupting hormone regulation
- Gut dysbiosis and inflammation, impairing hormone metabolism and clearance
- Nutrient deficiencies (B vitamins, glutathione, magnesium) reducing detoxification capacity
How Did We Get Here?
Signs & Symptoms
Patients with hormone toxicity may present with:
- Weight gain and fluid retention due to estrogen or cortisol excess
- Acne, oily skin, and hair thinning from excess androgens (testosterone, DHT)
- Mood swings, anxiety, or depression due to hormone dysregulation
- Irregular menstrual cycles or heavy bleeding in females
- Low libido and erectile dysfunction in males
- Gynecomastia and breast tenderness (increased estrogen effects in men)
- Fatigue and brain fog from metabolic and endocrine dysfunction
Lab Test Findings
| Lab Test | Expected Changes | Optimal Range |
| Dihydrotestosterone (DHT, Male) | Increased | 50.00-65.00 ng/dL |
| Estradiol (E2, Male) | Increased | 24.00-39.00 pg/mL |
| Estrogen (Female) | Increased or Decreased | 80-250 pg/mL |
| Estrone | Increased | 0-125 pg/mL |
| Free Testosterone (Female, Calculated) | Increased or Decreased | 0.8-1.2 pg/mL |
| HDL Cholesterol | Decreased | 55.00-93.00 mg/dL |
| Hemoglobin (Female) | Decreased | 13.50-14.50 g/dL |
| Progesterone (Male) | Decreased | 0.20-0.90 ng/dL |
| RBC (Male) | Decreased | 4.20-4.90Cells/µL |
| Testosterone (Total, Male) | Increased or Decreased | 700.00-1100.00 ng/dL |
How Do We Treat It?
Functional Medicine Approach
Treatment focuses on detoxifying excess hormones, reducing inflammation, and optimizing endocrine function.
Supplement Protocol
Supplement Function Dosage & Frequency
| Advanced Vita-Biotic R | Supports gut microbiome & immune function | 1 capsule with food, daily |
| Endura | Electrolyte balance & hydration support | 1 packet with or without food, three times daily |
| D-Mannose Powder | Prevents bacterial adhesion to gut lining | 1 tsp of powder with food, twice daily |
| Vita-Digestyzyme | Supports digestion & enzymatic function | 2 capsule 20-30 minutes prior to food, twice daily |
| Vita-Candid | Antifungal & microbiome support | 2 capsules 20-30 minutes prior to food, twice daily |
| Hormone Plus | Support balanced hormone levels and overall endocrine health | 2 capsules without food, daily |
| CoQ-10 300 mg | Mitochondrial & cardiovascular support | 2 capsules with food, daily |
| V-Inflamma | Reduces systemic inflammation | 1 capsule without food, daily |
| Vita DIM | Hormonal & detoxification support | 3 capsules with or without food, daily |
| Vita Defense | Immune system support | 1 capsule without food, daily |
| Vita-Glutathione | Antioxidant & cellular detoxification | 1 capsule with or without food, daily |
| V-Pax | Neurotransmitter & adrenal support | 2 capsules with or without food, twice daily |
| Vita B Methyl | Supports methylation & energy production | 1 capsule without food, daily |
| Magnesium | Supports muscle function & relaxation | 2 capsules with or without food, daily |
| V-Collagen | Supports gut lining & joint health | 1 scoop of powder without food, daily |
| SBI Powder | Immunoglobulin support for gut healing | 1 scoop of powder in cold liquids without food, daily |
| Gluta Protect | Antioxidant & gut barrier protection | 1 scoop of powder without food, daily |
| Vita Microbe | Comprehensive probiotic support | 3 capsules with or without food, daily |
| Vita Buffered C Powder | Immune & antioxidant support | ¼ scoop of powder with food, twice daily |
| Vita-Biotic | Supports microbiome balance | 4 capsule without food, daily |
| Vita-Flux | Nitric oxide & vascular health support | 2 capsules 20-30 minutes prior to food, twice daily |
Additional Lifestyle Interventions:
- Increase fiber intake (flaxseeds, leafy greens) to support estrogen detoxification
- Consume cruciferous vegetables (broccoli, cauliflower, kale) to enhance hormone metabolism
- Avoid endocrine disruptors (plastics, synthetic fragrances, pesticides)
- Support liver detoxification with milk thistle, turmeric, and dandelion root
- Exercise regularly to optimize hormone balance and metabolism
- Reduce stress and support adrenal health through mindfulness, sleep optimization, and adaptogens