Parathyroid Hyperfunction
What Does It Mean?
Parathyroid Hyperfunction occurs when the parathyroid glands produce excessive amounts of parathyroid hormone (PTH), leading to imbalances in calcium and phosphorus metabolism. This dysfunction can result in systemic mineral dysregulation, increased bone turnover, and potential cardiovascular and kidney complications.
How Did We Get There?
Root Causes
- Overproduction of Parathyroid Hormone (PTH) – Leads to excessive calcium release from bones and increased renal calcium reabsorption.
- Nutrient Imbalances – Deficiencies or excesses in vitamin D, magnesium, or phosphorus can contribute to dysregulated parathyroid function.
- Chronic Kidney Disease – Impaired renal function can alter calcium-phosphorus balance, leading to secondary hyperparathyroidism.
- Bone Resorption & Loss – Excess PTH stimulates bone breakdown, increasing fracture risk.
- Metabolic Dysfunction & Endocrine Imbalances – Disruptions in endocrine signaling can exacerbate parathyroid dysfunction.
Signs & Symptoms
- Hypercalcemia (elevated calcium levels)
- Bone pain and fragility fractures
- Kidney stones due to excessive calcium excretion
- Fatigue, muscle weakness, and cognitive dysfunction
- Abdominal discomfort or nausea
- Increased thirst and frequent urination
Diagnostic Criteria
Diagnosis is based on clinical presentation and lab markers that assess calcium and phosphorus balance.
Lab Test Findings
| Lab Test Name | Expected Changes | Optimal Range |
| Calcium | Elevated | 8.90-9.50 mg/dL |
| Calcium: Phosphorus Ratio | Increased | 2.30-3.20 ratio |
| Phosphorus (Phosphate) | Decreased | 3.00-4.00 mg/dL |
How Do We Treat It?
Functional Medicine Approach
Parathyroid Hyperfunction is primarily managed through endocrine specialist intervention. However, a functional medicine approach can support bone health, optimize calcium metabolism, and reduce systemic inflammation.
Supplement Protocol
| Refer to Endocrinologist | Given the complexity of parathyroid disorders, direct endocrine consultation is recommended for appropriate intervention. | As directed |
Additional Lifestyle Interventions:
- Bone Support & Mineral Balance – Ensure adequate magnesium and vitamin D intake to regulate calcium metabolism.
- Hydration & Kidney Support – Maintain proper hydration to prevent kidney stone formation.
- Dietary Adjustments – Reduce dietary calcium intake if hypercalcemia is present; balance phosphorus intake through whole foods.
- Monitor for Secondary Causes – Evaluate potential underlying conditions such as chronic kidney disease or endocrine dysfunction.