Fatigue and General Malaise
What Does It Mean?
Fatigue and general malaise refer to a state of persistent tiredness, low energy, and overall discomfort that is not relieved by rest. This dysfunction may stem from metabolic imbalances, hormonal dysregulation, chronic inflammation, or nutrient deficiencies. Functional Medicine seeks to identify and address the root causes of fatigue, optimizing energy production and restoring vitality.
How Did We Get There?
Root Causes:
- Mitochondrial Dysfunction – Impaired energy production at the cellular level due to oxidative stress or nutrient deficiencies.
- Adrenal Dysregulation – Chronic stress leading to dysregulated cortisol levels and poor energy resilience.
- Thyroid Dysfunction – Low thyroid hormone levels contributing to slow metabolism and persistent fatigue.
- Inflammation & Immune Activation – Chronic infections, gut imbalances, or autoimmunity can lead to systemic fatigue.
- Nutrient Deficiencies – Low levels of key vitamins and minerals involved in energy metabolism (e.g., B vitamins, magnesium, CoQ10).
- Blood Sugar Dysregulation – Hypoglycemia or insulin resistance leading to fluctuating energy levels.
Signs & Symptoms:
- Persistent tiredness despite adequate sleep
- Brain fog and difficulty concentrating
- Muscle weakness and sluggish metabolism
- Low motivation and mood instability
- Sensitivity to stress and poor recovery from exertion
- Cold intolerance and unexplained weight changes
How Do We Treat It?
A Functional Medicine approach focuses on enhancing mitochondrial function, supporting adrenal health, balancing blood sugar, and optimizing micronutrient levels to restore energy and overall well-being.
Supplement Protocol
| Supplement | Function | Dosage & Frequency |
| V-Pax | Supports neurotransmitter balance and energy | 2 capsules with food, daily |
| Vita B Methyl | Supports methylation and energy production | 1 capsule with food, daily |
| CoQ-10 300 mg | Enhances mitochondrial energy and cardiovascular function | 1 capsule with food, daily |
Additional Lifestyle Interventions:
- Optimize Sleep & Circadian Rhythms: Maintain a consistent sleep schedule and limit blue light exposure before bed.
- Balance Blood Sugar: Eat protein and healthy fats at each meal to stabilize energy levels.
- Support Mitochondrial Function: Engage in light physical activity and consume antioxidant-rich foods.
- Manage Stress & Adrenal Function: Incorporate mindfulness practices, adaptogenic herbs, and proper hydration.
- Improve Gut Health: Address dysbiosis and nutrient absorption with probiotics and digestive support.