Glutathione Deficiency
What Does It Mean?
Glutathione is the body's most powerful antioxidant, essential for detoxification, immune function, and cellular protection. A deficiency in glutathione can contribute to increased oxidative stress, inflammation, toxin accumulation, and impaired immune responses. Functional Medicine aims to restore optimal glutathione levels by identifying underlying imbalances and implementing targeted interventions.
How Did We Get There?
Root Causes:
- Increased Oxidative Stress – Chronic inflammation and toxin exposure deplete glutathione levels.
- Nutrient Deficiencies – Low levels of precursors such as N-acetylcysteine (NAC), vitamin C, and selenium reduce glutathione production.
- Poor Detoxification – Impaired liver function reduces glutathione synthesis.
- Chronic Illness & Autoimmunity – Conditions like chronic infections and autoimmunity accelerate glutathione depletion.
- Aging & Mitochondrial Dysfunction – Natural aging processes reduce cellular glutathione levels.
- Heavy Metal & Environmental Toxin Exposure – Increased toxin burden increases glutathione utilization.
Signs & Symptoms:
- Fatigue and low energy
- Increased susceptibility to infections
- Chronic inflammation and joint pain
- Brain fog and cognitive decline
- Poor liver function and toxin sensitivity
- Skin issues
Lab Test Findings
(Note: Additional lab tests may be referenced for a comprehensive evaluation.)
| Lab Test Name | Expected Changes | Optimal Range |
| Glutathione | Decreased in cases of deficiency | 373.00-838.00 uM |
How Do We Treat It?
A Functional Medicine approach focuses on boosting glutathione production, reducing oxidative stress, and optimizing detoxification pathways to restore balance and improve health.
Supplement Protocol
| Supplement | Function | Dosage & Frequency |
| Vita-Glutathione | Direct glutathione support for cellular protection | 3 capsules with or without food, daily |
Additional Lifestyle Interventions:
- Reduce Toxin Exposure: Avoid processed foods, pesticides, and environmental pollutants.
- Support Liver Function: Increase intake of cruciferous vegetables, turmeric, and milk thistle.
- Manage Stress & Improve Sleep: Implement relaxation techniques and maintain a regular sleep schedule.
- Exercise & Movement: Moderate exercise enhances glutathione production and detoxification.