Hypoproteinemia
What Does It Mean?
- Hypoproteinemia is a condition characterized by abnormally low levels of protein in the blood, which can lead to impaired physiological function and systemic imbalances.
- This dysfunction may result from malnutrition, liver disease, kidney dysfunction, or malabsorption disorders.
- Functional medicine focuses on identifying and addressing the root causes, such as nutrient deficiencies, inflammation, and metabolic imbalances.
How Did We Get Here?
Root Causes & Contributing Factors:
- Nutritional Deficiencies: Inadequate protein intake due to poor diet, malabsorption, or increased protein catabolism.
- Liver Dysfunction: The liver plays a key role in protein synthesis, and conditions like cirrhosis can impair this process.
- Kidney Dysfunction: Excessive protein loss through the urine due to nephrotic syndrome or chronic kidney disease.
- Inflammation & Gut Disorders: Chronic inflammation and gastrointestinal disorders (such as Crohn’s disease and celiac disease) can impair nutrient absorption and protein metabolism.
Signs & Symptoms:
- Edema (swelling in the legs, ankles, and feet due to low oncotic pressure).
- Muscle wasting and weakness.
- Fatigue and poor immune function.
- Brittle nails and hair loss.
- Delayed wound healing and increased susceptibility to infections.
Lab Test Findings
The following lab tests help evaluate hypoproteinemia and its underlying causes:
| Lab Test Name | Expected Changes | Optimal Range |
| Albumin | Decreased | 4.50-5.00 g/dL |
| Blood Urea Nitrogen (BUN) | Altered | 10.00-16.00 mg/dL |
| Calcium : Albumin Ratio | Altered | 0.00-2.18 |
| Creatinine | Altered | 0.80-1.10 mg/dL |
| Gamma Glutamyl Transferase (GGT) | Altered | 10.00-30.00 U/L |
| Total Protein | Decreased | 6.90-7.4 g/dL |
| Triglycerides, Serum | Altered | 70.00-80.00 mg/dL |
How Do We Treat It?
Treatment focuses on restoring protein levels, improving digestion, and optimizing nutrient absorption.
Supplement Protocol
| Supplement | Function | Dosage & Frequency |
| Perfect Protein | Supports protein synthesis and muscle repair | 1 scoop of protein powder with or without food, daily |
Additional Lifestyle Interventions:
- Increase Protein Intake: Consume high-quality protein sources such as lean meats, fish, eggs, and plant-based proteins.
- Optimize Digestion: Use digestive enzymes and probiotics to enhance protein absorption.
- Support Liver Function: Include liver-supportive foods such as leafy greens, beets, and milk thistle.
- Address Kidney Health: Monitor protein intake and hydration to support renal function.