COQ-10 Deficiency
What Does It Mean?
Coenzyme Q10 (CoQ10) is a vital antioxidant and a key component in mitochondrial energy production. It plays a crucial role in ATP synthesis, cellular protection, and cardiovascular health. A deficiency in CoQ10 can lead to impaired energy production, increased oxidative stress, and reduced cellular function, affecting multiple organ systems.
How Did We Get There?
Root Causes:
- Aging: CoQ10 levels naturally decline with age.
- Chronic Disease States: Conditions like cardiovascular disease, neurodegenerative disorders, and diabetes deplete CoQ10 levels.
- Statin Use: Statin medications inhibit HMG-CoA reductase, the enzyme needed for CoQ10 synthesis.
- Mitochondrial Dysfunction: Impaired energy production leads to increased demand for CoQ10.
- Poor Nutrient Absorption: GI issues, dysbiosis, or liver dysfunction can impair CoQ10 absorption.
Signs & Symptoms:
- Chronic fatigue and low energy levels
- Muscle weakness, cramping, or pain (especially in statin users)
- Brain fog, cognitive decline, and memory issues
- Cardiovascular concerns (high blood pressure, heart palpitations)
- Increased susceptibility to oxidative stress and inflammation
- Poor exercise tolerance and prolonged recovery times
Lab Test Findings
| Lab Test Name | Expected Changes | Optimal Range |
| Coenzyme Q10 | Decreased | 1.0-2.0 ug/mL |
How Do We Treat It?
Functional Medicine Approach
The treatment protocol aims to replenish CoQ10 levels, improve mitochondrial function, and enhance overall cellular energy production.
Supplement Protocol
| Supplement | Function | Dosage & Frequency |
| CoQ-10 300 mg | Supports mitochondrial ATP production and antioxidant function | 2 capsules with food, daily |
Additional Lifestyle Interventions:
- Optimize Diet: Increase intake of CoQ10-rich foods (fatty fish, organ meats, nuts, and seeds).
- Manage Statin-Induced Deficiency: If applicable, consider CoQ10 supplementation alongside statin therapy.
- Improve Mitochondrial Health: Engage in regular physical activity and intermittent fasting.
- Reduce Oxidative Stress: Consume antioxidant-rich foods and minimize environmental toxin exposure.
- Support Cellular Energy Production: Ensure adequate sleep and hydration.