What Does It Mean?
Dehydroepiandrosterone (DHEA) is a crucial precursor hormone produced by the adrenal glands, contributing to the production of estrogen and testosterone. Low DHEA levels in females can indicate adrenal insufficiency, chronic stress, or hormonal imbalances. Functional Medicine focuses on identifying root causes such as adrenal dysfunction, chronic inflammation, and metabolic imbalances to restore optimal hormone levels.
How Did We Get Here?
Root Causes:
- Adrenal Fatigue & Chronic Stress – Excessive cortisol production depletes DHEA levels over time.
- Hormonal Imbalances – Disruptions in estrogen, progesterone, and testosterone affect DHEA production.
- Inflammation & Autoimmune Dysfunction – Chronic systemic inflammation impairs adrenal function.
- Nutrient Deficiencies – Low levels of essential vitamins and minerals hinder hormone synthesis.
- Metabolic Dysfunction & Blood Sugar Imbalances – Insulin resistance and poor metabolic health impact adrenal hormone production.
Signs & Symptoms:
- Persistent fatigue and low energy
- Reduced libido and sexual dysfunction
- Poor muscle tone and difficulty maintaining muscle mass
- Increased body fat, especially around the abdomen
- Mood instability, depression, and anxiety
- Dry skin, hair thinning, and brittle nails
Lab Test Findings
(Note: Additional lab tests may be referenced for a comprehensive evaluation.)
| Lab Test Name | Expected Changes | Optimal Range |
| DHEA Sulfate | Decreased | 150.00-250.00 ug/dL |
| Hemoglobin | Altered | 13.50-14.50 g/dL |
How Do We Treat It?
A Functional Medicine approach focuses on supporting adrenal health, optimizing hormone production, reducing inflammation, and addressing metabolic imbalances to restore DHEA levels.
Supplement Protocol
| Supplement | Function | Dosage & Frequency |
| DHEA 5 mg | Supports adrenal function and hormone production | 2 tablets without food, daily |
Additional Lifestyle Interventions:
- Reduce Stress & Support Adrenal Function: Implement mindfulness practices, deep breathing, and adequate sleep.
- Optimize Nutrient Intake: Consume a diet rich in healthy fats, lean proteins, and whole foods to support hormone synthesis.
- Balance Blood Sugar: Avoid refined sugars and processed foods that contribute to metabolic dysfunction.
- Incorporate Strength Training & Movement: Resistance training helps support muscle mass and overall hormone balance.
- Improve Sleep Hygiene: Prioritize restful sleep to enhance adrenal recovery and hormone regulation.