Hypoproteinemia

What Does It Mean?

• Hypoproteinemia is a condition characterized by abnormally low levels of protein in the blood, which can lead to impaired physiological function and systemic imbalances.
• This dysfunction may result from malnutrition, liver disease, kidney dysfunction, or malabsorption disorders.
• Functional medicine focuses on identifying and addressing the root causes, such as nutrient deficiencies, inflammation, and metabolic imbalances.

How Did We Get Here?

Root Causes & Contributing Factors:

• Nutritional Deficiencies: Inadequate protein intake due to poor diet, malabsorption, or increased protein catabolism.
• Liver Dysfunction: The liver plays a key role in protein synthesis, and conditions like cirrhosis can impair this process.
• Kidney Dysfunction: Excessive protein loss through the urine due to nephrotic syndrome or chronic kidney disease.
• Inflammation & Gut Disorders: Chronic inflammation and gastrointestinal disorders (such as Crohn’s disease and celiac disease) can impair nutrient absorption and protein metabolism.

Signs & Symptoms:

• Edema (swelling in the legs, ankles, and feet due to low oncotic pressure).
• Muscle wasting and weakness.
• Fatigue and poor immune function.
• Brittle nails and hair loss.
• Delayed wound healing and increased susceptibility to infections.

Lab Test Findings

The following lab tests help evaluate hypoproteinemia and its underlying causes:

Lab Test Name	Expected Changes	Optimal Range
Albumin	Decreased	4.50-5.00 g/dL
Blood Urea Nitrogen (BUN)	Altered	10.00-16.00 mg/dL
Calcium : Albumin Ratio	Altered	0.00-2.18
Creatinine	Altered	0.80-1.10 mg/dL
Gamma Glutamyl Transferase (GGT)	Altered	10.00-30.00 U/L
Total Protein	Decreased	6.90-7.4 g/dL
Triglycerides, Serum	Altered	70.00-80.00 mg/dL

How Do We Treat It?

Treatment focuses on restoring protein levels, improving digestion, and optimizing nutrient absorption.

Supplement Protocol

Supplement	Function	Dosage & Frequency
Perfect Protein	Supports protein synthesis and muscle repair	1 scoop of protein powder with or without food, daily

Additional Lifestyle Interventions:

• Increase Protein Intake: Consume high-quality protein sources such as lean meats, fish, eggs, and plant-based proteins.
• Optimize Digestion: Use digestive enzymes and probiotics to enhance protein absorption.
• Support Liver Function: Include liver-supportive foods such as leafy greens, beets, and milk thistle.
• Address Kidney Health: Monitor protein intake and hydration to support renal function.